Posture-dependent Human 3He Lung Imaging in an Open-access MRI System
نویسندگان
چکیده
منابع مشابه
Posture-dependent human 3He lung imaging in an open-access MRI system: initial results.
RATIONALE AND OBJECTIVES The human lung and its functions are extremely sensitive to orientation and posture, and debate continues as to the role of gravity and the surrounding anatomy in determining lung function and heterogeneity of perfusion and ventilation. However, study of these effects is difficult. The conventional high-field magnets used for most hyperpolarized (3)He magnetic resonance...
متن کاملAn open-access, very-low-field MRI system for posture-dependent 3He human lung imaging.
We describe the design and operation of an open-access, very-low-field, magnetic resonance imaging (MRI) system for in vivo hyperpolarized 3He imaging of the human lungs. This system permits the study of lung function in both horizontal and upright postures, a capability with important implications in pulmonary physiology and clinical medicine, including asthma and obesity. The imager uses a bi...
متن کامل3He lung imaging in an open access, very-low-field human magnetic resonance imaging system.
The human lung and its functions are extremely sensitive to gravity; however, the conventional high-field magnets used for most laser-polarized (3)He MRI of the human lung restrict subjects to lying horizontally. Imaging of human lungs using inhaled laser-polarized (3)He gas is demonstrated in an open-access very-low-magnetic-field (<5 mT) MRI instrument. This prototype device employs a simple,...
متن کاملImaging lung microstructure in mice with hyperpolarized 3He diffusion MRI.
Quantitative measurement of lung microstructure is of great significance in assessment of pulmonary disease, particularly in the earliest stages. The technique for MRI-based 3He lung morphometry was previously developed and validated for human lungs, and was recently extended to ex vivo mouse lungs. The technique yields accurate, quantitative information about the microstructure and geometry of...
متن کامل3He MRI-based assessment of posture-dependent regional ventilation gradients in rats.
A recently developed method for quantitative assessment of regional lung ventilation was employed for the study of posture-dependent ventilation differences in rats. The measurement employed hyperpolarized (3)He MRI to detect the build-up of the signal intensity after increasing numbers of (3)He breaths, which allowed for computation of a regional ventilation parameter. A group of six anestheti...
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ژورنال
عنوان ژورنال: Academic Radiology
سال: 2008
ISSN: 1076-6332
DOI: 10.1016/j.acra.2007.10.010